In the first phase of the study, half of the participants will receive CBD and the other half a placebo; both in the form of self-administered, flavored oral drops. In the second phase, after a period to allow participants’ systems to “washout,” the groups will be switched with the half that originally received CBD getting the placebo while the initial placebo group receives CBD. Investigators will be blinded to which participants are receiving which treatment until after testing is completed. However, if life is to go on safely and economies are to survive, people may be willing to take the first treatment that arrives, CBD-based or not. The research conducted by Stero Therapeutics and the University of Lethbridge’s team could open the doors to unexpected new ways to prevent, and treat, coronavirus.
Cannabis sativa strains are high in CBD, one of cannabis’s core chemicals with anti-inflammatory properties. Following a study conducted at the University of Lethbridge in Alberta, Canada, researchers believe that strong cannabis strains could prove valuable in preventing or treating coronavirus infections. Further studies will be required to verify the research and facilitate the creation of CBD-centric solutions suitable for Covid-19 patients.
However, as these extracts are high in CBD but extremely low in THC, people would be unable to experience the high associated with cannabis. During the Lethbridge study, the team screened the cannabis sativa extracts using artificial 3D models of human intestinal, oral, and airway tissues. The researchers discovered that 13 of the extracts high in CBD were capable of modulating ACE2 effectively. University of Lethbridge researchers worked under a research license from Health Canada, the government department overseeing Canada’s federal health policy, to develop more than 800 new cannabis sativa lines and extracts.
Current Cbd Clinical Trials
Freeman and his colleagues stress these findings shouldn’t prompt people to run out and purchase CBD to "self-medicate" if they’re trying to cut down on cannabis use. However, by the study’s conclusion, daily CBD doses of 400 and 800 milligrams were both found to reduce participants’ cannabis intake. Specifically, these doses reduced THC levels in the urine by -94.21ng/mL and -72.02ng/mL, respectively.
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Other parties are exploring the potential for treating COVID-19 with cannabis, including Israeli canna-tech company Stero Therapeutics. The study has yet to be peer reviewed and verified, but the team believes that these sativa lines could be used to develop such preventive treatments as mouthwashes or “throat-gargle” solutions.
However, further studies will be required to verify the research and facilitate the creation of CBD-centric solutions suitable for COVID-19 patients. However, the trials had to be canceled when these patients became unavailable and a number of other medical centers in Israel shut their coronavirus wards down due to a massive reduction in new cases. This startup was ready to start its research into CBD’s effect on the coronavirus at the height of the global crisis. It planned to start clinical trials with 10 patients, all affected CBD one by COVID-19, at Petah Tikva’s Rabin Medical Center.
- In pooled data of 17 observational studies, Stockings et al. found that CBD at 20 mg/kg/day resulted in 48.5% of patients having a 50% reduction in seizures and QoLCE scores improved in 55.8% .
- Chemotherapy typically entails vomiting and nausea, making it difficult to eat.
- An “entourage” effect in which the clinical efficacy of cannabinoids when used in combination are greater than when used individually has been demonstrated in several animal models of epilepsy but has yet to be reported for human trials (25–27).
- However, research has suggested CBD can be effective at increasing patients’ appetites in addition to lowering any pain they have related to cancer.
It’s impossible to overdose on pure CBD, but synthetic knock-offs can be poisonous. In 2019, the American Association of Poison Control Centers put out an alert noting “growing concern” about CBD products, with national calls about CBD rocketing from just over 100 in 2017 to more than 1,500 last year. With no scientific proof that CBD works and is safe for children, Mitchell said stimulant-based medications like Adderall are a better option than CBD. “We know much more about one than the other, so the choice is simple,” he said. But he understands why a parent might consider CBD as an alternative, he said, given that it is typically seen as a gentle drug with few side effects.